9 research outputs found
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Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine
Background: Paraneoplastic chorea is typically a subacute progressive hyperkinetic movement disorder. The mainstay of treatment is managing the underlying neoplasm. However, the clinical course may be variable, and effective symptomatic management can precede the start of cancer treatment.
Case report: A 63-year-old man presented with insidious onset, slowly progressive generalized chorea for 1 year, later diagnosed as anti-CV2/CRMP5 autoantibody positive paraneoplastic chorea. His chorea was markedly improved with intravenous amantadine.
Discussion: In patients with anti-CV2/CRMP5 autoantibody-related chorea, sequential follow-up of brain magnetic resonance imaging reveals progression from active inflammation to atrophy. Our report highlights the efficacy of intravenous amantadine in paraneoplastic chorea
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Author Response to Letter to the Editor
This is an author response to the letter by doctors Nicholas Doher and Harsh V Gupta. Despite the narrow indication for the dopamine transporter (DAT) scan to distinguish essential tremor from Parkinsonian syndromes, as approved by the Food and Drug Administration (FDA), DAT imaging is utilised for various other clinical symptoms in patients with parkinsonism. DAT scan is the only non-invasive modality developed to assess functional integrity of the dopaminergic system currently used in clinical practice, and could give valuable clinical information for selected patients. The authors believe that the approved indication of the DAT scan will be broadened to meet its versatile diagnostic potential
DIOSPYROS LOTUS: MICROPROPAGATION AND ANTIOXIDANT ACTIVITY
Diospyros lotus is a deciduous tree that is native to the Middle East and south Asia, especially China, Korea, and Japan. It bears edible small fruits in autumn and leaves are used widely in folk medicine for their medicinal properties. A protocol for the date plum (Diospyros lotus) was developed. For shoot proliferation, in vitro nodal and apical explants were cultured on various media containing 0.5-2.0 mg/l BA, kinetin, or TDZ. WPM medium supplemented with 0.5 m/l BA displayed the highest proliferation rate (4-7 shoots per explant). The rooting was optimized using MS medium supplemented with 0.5 mg/l IBA with 3-5 roots after 2 months of culture. The rooted plantlets were successfully acclimatized and transferred to potting mix with 92% survival. Antioxidant properties of in vivo grown tissues were evaluated using various assays. The levels of total phenolics and flavonoids of the leaves extracts were also determined. The alcohol extract of date plum leaves had good phenolic (445. 6 mg/g) and flavonoid (260.9 mg/g) contents, and showed the strong antioxidant and free-radical scavenging activity (scavenged 92.1% of DPPH at 250 ug/ml). Leaf extracts had higher activities of anti-oxidant-related enzymes including superoxide dismutase (SOD; 20.5 U/mg protein), catalase (CAT; 4.9 U/mg protein), and ascorbate peroxidase (APX; 105.8 U/mg protein) than mature seed extracts (SOD, 2.1 U/mg protein; CAT, 74.5 U/mg protein; APX, 3.7 U/mg protein). These results establish the antioxidant potential of date plum, which could be used as natural antioxidant source